#HAZEL EYES COLOR SKIN#
Variation in human skin and eye color is substantial and especially apparent in admixed populations, yet the underlying genetic architecture is poorly understood because most genome-wide studies are based on individuals of European ancestry. Both of their sons in generation III (III-7 & III-8) had hazel eyes while the daughter (III-6) had brown eyes. Further, the second daughter having hazel eyes (II-2) also married a male with brown eyes and they produced one daughter and two sons. The first daughter with hazel eyes (II-2) got married to a brown eyed male (II-1) and they produced five children in generation III which included two daughters with hazel eyes (III-1 & III-2) and three sons having brown eyes (III-3, III-4 & III-5). They produced ten children which included two daughters who had hazel eyes (II-2 & II-4). If one looks at the pedigree, it may be observed that the founders of the pedigree did not have hazel eyes. Family B (The maternal side): In Family B, information about the eye colour could be recorded for five generations and it was arranged in the form of a pedigree. They produced three daughters (III-6, III-7 & III-8) and three sons (III-9, III-10 & III-11), all of whom had brown eyes. One of the males in generation II (II-8) who had brown eyes married a female with brown eyes. The female (III-4) married a male with brown eyes and they produced two daughters (IV-1 & IV-2), both of whom had brown eyes. So, in generation III, it was observed that one female (III-4) had hazel eyes, while the other two females had brown eyes (III-1 & III-2) and the male (III-5) also had brown eyes.
The female (II-2) married a brown eyed male (II-1) and together they produced four children in generation III. This might indicate that the parents in generation I might be the carriers of the genes for the hazel eyes. Out of the seven offspring produced, one daughter (II-2) expressed hazel eyes, while her siblings had brown eyes. They produced seven children in generation II. As per the pedigree constructed for Family A, the founders had brown eyes. Pedigree of inheritance of hazel eye colour in Case I Family A (The paternal side): For family A, it was possible to record the eye colour information of the four generations. Other to produce variations in the eye colour and the role of the climate on the production of The finer mechanisms by which different genes interact with each Produce the eye colour but the climate/environment might have its own influence on theĮxpression of these genes. Since, there are many genes responsible for production of eyeĬolour like OCA2, BEY2, GEY, HERC2 etc., primarily the expression of these genes might Thus,Ĭlimate might have a role in the eye pigmentation due to differential expression of the genes Showing continuous expression of hazel eyes for only two generations in few lineages. With humid subtropical climate had comparatively lesser number of persons with hazel eyes, Two cases involving families from Gorakhpur, Uttar Pradesh, and Darbhanga, Bihar, regions Showed higher occurrence of hazel eyes in the family, with many lineages showing continuousĮxpression of hazel eyes for three generations and in some for even four generations.
One case from Kangra, Himachal Pradesh, a region with mild temperate climate, It also showed that the hazelĮye colour is not sex-linked and moreover, that it is neither autosomal dominant nor autosomal Inheritance does not follow the Mendelian inheritance patterns. Our pedigree study suggested that the hazel eye colour Of brown eye colour, are found in Indian subcontinent, but their occurrence is comparatively The eye colour in humans is a complex and polygenic trait.
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